ABSORBABLE, PERMEABILITY-MODULATED BARRIER COMPOSITES AND APPLICATIONS THEREOF

摘要

Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.

主权项

1. An absorbable, permeability-modulated barrier composite comprising:
a. at least three physiocochemically distinct components; b. a first component comprising a flexible film comprising a synthetic absorbable polymer selected from the group consisting of
i. a polyaxial copolyester derived from at least two monomers selected from the group consisting of glycolide, lactide, ε-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one and a morpholinedione;ii. a polyether ester derived from a polyether-glycol that is grafted with at least one monomer selected from the group consisting of glycolide, lactide, ε-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one and a morpholinedione; andiii. a polyether-ester-urethane derived from a polyether-glycol that is grafted with at least one monomer selected from the group consisting of glycolide, lactide, ε-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one and a morpholinedione, to form a polyether ester glycol, where the polyether ester glycol is interconnected by urethane linkages formed through the reaction of said polyether ester glycol with an aliphatic diisocyanate; c. a second component comprising a knitted mesh; and d. a third component comprising an electrostatically spun, non-woven microfibrous fabric;wherein the flexible film is adjoined directly to the knitted mesh, and the knitted mesh is adjoined directly to the microfibrous fabric, to form a layered composite.