| 发明名称 |
METHODS AND COMPOSITIONS FOR TREATING MULTIPLE MYELOMA |
| 摘要 |
Methods and compositions for sensitizing multiple myeloma cells to treatment with IMiDs are provided. Aspects include methods of administering AR-42 and an IMiD (e.g., lenalidomide, pomalidomide) to multiple myeloma patients. |
| 申请公布号 |
US2017056346(A1) |
申请公布日期 |
2017.03.02 |
| 申请号 |
US201615254900 |
申请日期 |
2016.09.01 |
| 申请人 |
Ohio State Innovation Foundation |
发明人 |
Pichiorri Flavia;Hoffmeister Craig |
| 分类号 |
A61K31/167;A61K31/454 |
主分类号 |
A61K31/167 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of sensitizing multiple myeloma cells to treatment with lenalidomide comprising administering AR-42 and lenalidomide to a patient in need treatment in an amount sufficient to achieve a blood or tissue concentration of at least about 0.5 to about 1 μM of AR-42 and at least about 391 to about 568 ng/ml of lenalidomide. |
| 地址 |
Columbus OH US |
