MICROCAPSULE FORMULATION AND METHOD FOR PRODUCING THE SAME

摘要

[Object] An object of the present invention is to provide a method for producing a microcapsule formulation using a biodegradable polymer, the method being capable of avoiding direct contact of a peptidic physiologically active substance with an organic solvent layer, and achieving a high encapsulation efficiency of the peptidic physiologically active substance.;[Method for Achieving the Object] The present invention provides a method for producing a microcapsule formulation comprising:
step A of adding a basic amino acid to an aqueous solvent containing a heavy metal salt of a peptidic physiologically active substance to obtain an amino acid-containing S/W suspension;step B of adding a basic amino acid to an organic solvent containing a biodegradable polymer to obtain an amino acid-containing polymer solution;step C of dispersing the amino acid-containing S/W suspension in the amino acid-containing polymer solution, which is an oil phase, to obtain an S/W/O emulsion;step D of dispersing the S/W/O emulsion in a water phase to obtain an S/W/O/W emulsion; andstep E of removing the organic solvent from the S/W/O/W emulsion.

主权项

1. A method for producing a microcapsule formulation comprising:
step A of adding a basic amino acid to an aqueous solvent containing a heavy metal salt of a peptidic physiologically active substance to obtain an amino acid-containing S/W suspension; step B of adding a basic amino acid to an organic solvent containing a biodegradable polymer to obtain an amino acid-containing polymer solution; step C of dispersing the amino acid-containing S/W suspension in the amino acid-containing polymer solution, which is an oil phase, to obtain an S/W/O emulsion; step D of dispersing the S/W/O emulsion in a water phase to obtain an S/W/O/W emulsion; and step E of removing the organic solvent from the S/W/O/W emulsion to obtain the microcapsule formulation.