发明名称 |
SUBCUTANEOUS ANTI-HLA-DR MONOCLONAL ANTIBODY FOR TREATMENT OF HEMATOLOGIC MALIGNANCIES |
摘要 |
The present invention concerns compositions and methods of use of anti-HLA-DR antibodies or fragments thereof. In preferred embodiments, the antibodies are subcutaneously administered to a human patient with a hematologic cancer or autoimmune disease. The subcutaneously administered anti-HLA-DR antibody is effective to treat hematologic cancer or autoimmune disease in patients that have relapsed from or are refractory to standard therapies for hematologic cancer or autoimmune disease, such as administration of anti-CD20 antibodies, such as rituximab. |
申请公布号 |
WO2017034906(A1) |
申请公布日期 |
2017.03.02 |
申请号 |
WO2016US47483 |
申请日期 |
2016.08.18 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
GOLDENBERG, David M.;WEGENER, William A. |
分类号 |
A61K39/395;A61K51/10;C07K16/28;C07K16/30;C07K16/46 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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