Substituted 2-thioxo-imidazolidin-4-ones and spiro analogues thereof, active anti-cancer ingredient, pharmaceutical composition, medicinal preparation, method for treating prostate cancer

摘要

The invention relates to novel (R)-stereoisomers of substituted 2-thioxo-imidazolidin-4-ones of formula 1, or spiro analogues thereof, which exhibit androgen receptor antagonist properties, variants of a method for producing same, and intermediate compounds for producing compounds of formula 1. Compounds of formula 1 can be used to produce a medicinal agent suitable for treating cancers, such as prostate cancer and breast cancer. The invention also relates to a pharmaceutical composition in the form of tablets, capsules and injections. In formula 1, R1 is OH, NH