| 主权项 |
1. A compound of formula (I): or a pharmaceutically acceptable salt, solvate, tautomer, stereoisomer or N-oxide thereof, wherein X, Y and Z are independently selected from the group consisting of N and CR5, with the proviso that at least one of X, Y and Z is N, and wherein each R5 is independently selected from the group consisting of hydrogen, a halogen atom, (C1-4)alkyl and (C1-4)alkyl substituted with one or more fluor atoms; m is 0, 1 or 2 and n is 1, 2 or 3 with the proviso that m+n is 1, 2 or 3; R1 is selected from the group consisting of
—(C1-6)alkylene-R6 wherein one or more carbon atoms in the alkylene group, each independently, are optionally substituted with one or more halogen atoms or with (CH2)2 to form a cyclopropyl moiety or with (CH2)3 to form a cyclobutyl moiety,—(C3-6)cycloalkylene-R6 in which one carbon atom in the (C3-6)cycloalkylene can optionally be replaced by oxygen,—(C1-3)alkylene-(C3-6)cycloalkylene-R6,—(C3-6)cycloalkylene-(C1-3)alkylene-R6 and—C(O)—(C1-4)alkylene-R6,wherein R6 is selected from the group consisting of —OH, —OPO3H2, —COOH, —COO(C1-4)alkyl and tetrazol-5-yl; R2 is absent, one or more substituents independently selected from the group consisting of a halogen atom, oxo, (C1-4)alkyl optionally substituted with one or more halogen atoms and (C1-4)alkoxy optionally substituted with one or more halogen atoms, or together with one of the carbon atoms in the N-containing ring forms a (C3-6)cycloalkyl; L1 is absent or wherein
* indicates the bond to ring A and ** indicates the bond to R3; andRing B is selected from the group consisting of (C3-7)cycloalkyl, (C4-7)cycloalkenyl, phenyl, pyridyl, thienyl and thiazolyl, each optionally substituted with one or more substituents independently selected from the group consisting ofhydroxy,cyano,a halogen atom,(C1-4)alkyl optionally substituted with one or more halogen atoms,(C3-6)cycloalkyl optionally substituted with one or more halogen atoms,(C1-4)alkoxy optionally substituted with one or more halogen atoms, andphenyl optionally substituted with one or more substituents independently selected from the group consisting of a halogen atom, (C1-4)alkyl optionally substituted with one or more halogen atoms, and (C1-4)alkoxy optionally substituted with one or more halogen atoms; and R3 is L2-R4, wherein:
L2 is absent or a group —W—(CH2)p-T- wherein:W is attached to L1 and selected from the group consisting of a bond, —O—, —CO—, —S—, —SO—, —SO2—, —NH—, —CH═CH—, —C(CF3)═CH—, CH═C(CF3)—, —CF2—CH2—, —CH2—CF2—, —CHF—CH2—, —CH2—CHF—, —CH2—O—, —O—CH2—, —O—CO—, —CO—O—, —CO—NH—, —NH—CO— and cyclopropylene;p is an integer from 0 to 10;one or more C atoms of (CH2)p are optionally substituted with one or two fluoro atoms, andT is absent or attached to R4 and selected from the group consisting of a bond, —O—, —S—, —SO—, —SO2—, —NH—, —CO—, —CH═CH—, and cyclopropylene,R4 is selected from the group consisting of:(C3-6)cycloalkyl, (C4-6)cycloalkenyl or an 8-10 membered bicyclic group, each optionally substituted with a substituent selected from the group consisting of a halogen atom, (C1-4)alkyl optionally substituted with one or more fluoro atoms and (C1-4)alkoxy optionally substituted with one or more fluoro atoms,phenyl, biphenyl or naphthyl, pyridyl, thienyl, thiazolyl optionally substituted with one or more substituents independently selected from the group consisting of:
a halogen atom,hydroxy,cyano,(C1-4)alkyl optionally substituted with one or more fluoro atoms,(C1-4)alkoxy optionally substituted with one or more fluoro atoms,—S—(C1-4)-alkyl,—SF5, and(C3-6)cycloalkyl optionally substituted with phenyl whereby said phenyl is optionally substituted with a substituent selected from the group consisting of (C1-4)alkyl and a halogen atom, andphenyl substituted with a substituent selected from the group consisting of phenoxy, benzyl, benzyloxy, phenylethyl and a monocyclic heterocycle, wherein each substituent is optionally substituted with one or more halogen atoms, (C1-4)alkyl, (C1-4)alkyl substituted with one or more fluoro atoms, (C1-4)alkoxy, or (C1-4)alkoxy substituted with one or more fluoro atoms. |
