摘要 |
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is a carbamate, ester, or ketone substituent (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement. |
申请人 |
ACHILLION PHARMACEUTICALS, INC. |
发明人 |
WILES, Jason, Allan;PHADKE, Avinash, S.;DESHPANDE, Milind;AGARWAL, Atul;CHEN, Dawei;GADHACHANDA, Venkat Rao;HASHIMOTO, Akihiro;PAIS, Godwin;WANG, Qiuping;WANG, Xiangzhu |