发明名称 |
HOMOALLYLAMINES AS FORMALDEHYDE-RESPONSIVE TRIGGERS |
摘要 |
Probes for formaldehyde (FA) including a homoallylamine trigger group attached to a detectable moiety are provided. Aspects of the probes include luminogenic or fluorogenic probes, such as a probe including a quencher in energy-receiving proximity to a fluroophore. Also provided are methods of using the probes for sensitive and bioorthogonal detection of FA in a sample. Aspects of the methods include selectively reacting the probe with the formaldehyde in the sample to a release (e.g., via a 2-aza- Cope rearrangement) a reporter group comprising a detectable moiety. Aspects of the methods detecting formaldehyde in a cell, tissue, organ or fluid in a subject. Also provided are compositions and kits including the subject probes that find use in practicing various embodiments of the subject methods. |
申请公布号 |
WO2017034927(A1) |
申请公布日期 |
2017.03.02 |
申请号 |
WO2016US47580 |
申请日期 |
2016.08.18 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CHANG, Christopher J.;BREWER, Thomas Francis;CHAN, Jefferson |
分类号 |
G01N21/64;C07C211/21;C09K11/06 |
主分类号 |
G01N21/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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