发明名称 |
Vaccine for the Prevention of Breast Cancer Recurrence |
摘要 |
Provided are methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER/neu oncogene, GP2, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission, including 5 patients having low to intermediate levels of HER2/neu expression. The methods comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as GM-CSF, and the GP2 peptide. The methods may further comprise administering a periodic booster vaccine dose as needed due to declining GP2-specific T cell immunity. Also provided are vaccine compositions for use in the 10 methods. |
申请公布号 |
AU2015203572(B2) |
申请公布日期 |
2017.03.02 |
申请号 |
AU20150203572 |
申请日期 |
2015.06.26 |
申请人 |
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. |
发明人 |
Peoples, George E.;Ponniah, Sathibalan |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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