Adjunct Material to Provide Controlled Drug Release

摘要

Adjunct material retained by a staple cartridge assembly is provided. The adjunct material provides elution of medicants therefrom such that release of one medicant regulates release of another medicant. A first medicant is released as a bolus dose substantially immediately upon delivery of the adjunct material to tissue. The second medicant is associated with the staple cartridge assembly in a manner such that release of the second medicant to tissue is regulated by the release of the first medicant.

主权项

1. A staple cartridge assembly for use with a surgical stapler, comprising:
a cartridge body having a plurality of staple cavities, each staple cavity having a surgical staple disposed therein; a bioabsorbable adjunct material releasably retained on the cartridge body and configured to be delivered to tissue by deployment of the staples in the cartridge body; and a first medicant component associated with a component of the staple cartridge assembly in a manner in which the first medicant is released as a bolus dose substantially immediately upon delivery of the adjunct material to tissue; and a second medicant component associated with a component of the staple cartridge assembly in a manner such that release of the second medicant component to tissue is regulated by the release of the first medicant component.