ETHER COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS
摘要
Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I" and I‴ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.
申请公布号
WO2017035411(A1)
申请公布日期
2017.03.02
申请号
WO2016US48793
申请日期
2016.08.25
申请人
ACHILLION PHARMACEUTICALS, INC.
发明人
WILES, Jason Allan;PHADKE, Avinash S.;DESHPANDE, Milind;AGARWAL, Atul;CHEN, Dawei;GADHACHANDA, Venkat Rao;HASHIMOTO, Akihiro;PAIS, Godwin;WANG, Qiuping;WANG, Xiangzhu;GREENLEE, William