METHOD OF MANUFACTURING TRANSDERMAL ABSORPTION SHEET AND TRANSDERMAL ABSORPTION SHEET

摘要

An object is to provide a method of manufacturing a transdermal absorption sheet and a transdermal absorption sheet that can suppress generation of air bubbles. In the method of manufacturing the transdermal absorption sheet that includes a drug solution filling step, a drug solution drying step, a base solution filling step, a base solution drying step, and a peeling-off step in that order, each step of at least from the drug solution filling step to the base solution drying step is performed in an environment with a temperature of 1° C. to 10° C.

主权项

1. A method of manufacturing a transdermal absorption sheet comprising, in this order:
a drug solution filling step of filling needle-shaped recesses of a mold, the needle-shaped recesses being arranged two-dimensionally, with a drug solution that is a polymer solution containing a predetermined amount of a drug; a drug solution drying step of drying the drug solution filled in the needle-shaped recesses to form a first layer containing a predetermined amount of a drug; a base solution filling step of filling the needle-shaped recesses on the first layer with a base solution that is a polymer solution not containing a predetermined amount of a drug; a base solution drying step of drying the base solution to form a second layer not containing a predetermined amount of a drug on the first layer; and a peeling-off step of peeling off the first layer and the second layer from the mold, wherein each step of at least from the drug solution filling step to the base solution drying step is performed in an environment with a temperature of 1° C. to 10° C.