| 发明名称 |
IL-15/IL-15RALPHA BASED CONJUGATES PURIFICATION METHOD |
| 摘要 |
The present invention relates to a method for preparing a composition comprising monomeric conjugates from a sample, said conjugate comprising (a) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and (b) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15Rα or derivatives thereof; wherein said method comprises the use of anion-exchange chromatography followed by a hydrophobic interaction chromatography; and to a pharmaceutical composition which can be obtained by such a method. |
| 申请公布号 |
US2017056874(A1) |
申请公布日期 |
2017.03.02 |
| 申请号 |
US201515123153 |
申请日期 |
2015.03.03 |
| 申请人 |
CYTUNE PHARMA |
发明人 |
BECHARD David;DEMARTINOFF Guy |
| 分类号 |
B01J41/20;B01D15/32;C07K1/18;C07K14/54;C07K14/715;C07K1/20;B01D15/36;B01D15/14 |
主分类号 |
B01J41/20 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for preparing a composition comprising monomeric conjugates from a sample, said conjugate comprising:
a) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and b) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15Rα or derivatives thereof; wherein said method comprises the use of anion-exchange chromatography followed by a hydrophobic interaction chromatography on said sample. |
| 地址 |
Nantes FR |
