ULTRAFILTRATION UNIT FOR CONTINUOUS BUFFER OR MEDIUM EXCHANGE FROM A PROTEIN SOLUTION

摘要

The invention relates to an ultrafiltration unit for continuous buffer or medium exchange, a method for continuous buffer or medium exchange in the ultrafiltration unit, and a plant in particular for (semi)continuous production of biopharmaceutical and biological macromolecular products in particular, such as proteins, e.g. monoclonal antibodies and vaccines, comprising the ultrafiltration unit according to the invention.

主权项

1. Unit for continuous ultrafiltration of a product stream which contains one or more biopharmaceutical and biological macromolecular products, comprising at least one capillary ultrafiltration module, wherein
at least one pump conveys the product stream into the capillaries of the ultrafiltration module, a positive displacement pump conveys the product stream from the capillaries and at least one further pump passes the washing fluid over the outside of the capillaries, the unit includes no measure for circulating the product stream and the washing fluid into the ultrafiltration module.