| 发明名称 |
OPIOID RECEPTOR MODULATORS AND USE THEREOF |
| 摘要 |
Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method for treating an opioid receptor-associated condition using a compound of Formula (I) and a pharmaceutical composition containing the same. |
| 申请公布号 |
US2017056377(A1) |
申请公布日期 |
2017.03.02 |
| 申请号 |
US201615207951 |
申请日期 |
2016.07.12 |
| 申请人 |
National Health Research Institutes ;Regents of the University of Minnesota |
发明人 |
Ueng Shau-Hua;Yeh Shiu-Hwa;Loh Horace;Chao Yu-Sheng |
| 分类号 |
A61K31/426;A61K31/454;A61K31/5377;G01N33/50;A61K31/422;A61K31/428;A61K31/485;A61K31/427;A61K31/4439 |
主分类号 |
A61K31/426 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An in vitro screening method of identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor, the method comprising:
treating cells that express the mu-opioid receptor with a test compound and a mu-opioid receptor antagonist, determining whether the mu-opioid receptor is activated, and identifying the test compound as an antagonist-to-agonist allosteric modifier if the mu-opioid receptor is activated. |
| 地址 |
Zhunan Town TW |
