发明名称 |
PHARMACEUTICALLY ACCEPTABLE SALTS OF ss-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF |
摘要 |
The present invention relates to new pharmaceutical salts of β-GPA which exhibit improved physical properties. In particular, the invention relates to salts of β-GPA with improved flow properties (e.g., improved Carr's index and/or Hausner ratio) such as fumarate salts, succinate salts, and oxalate salts. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts of β-GPA, as well as methods of treating cancer including administration of a formulation including a β-GPA salt of the invention to a subject in need thereof. |
申请公布号 |
US2017056353(A1) |
申请公布日期 |
2017.03.02 |
申请号 |
US201615281329 |
申请日期 |
2016.09.30 |
申请人 |
Rgenix, Inc. |
发明人 |
MARTINEZ Eduardo J.;GRILL Andreas G.;SINGH Aniruddh;KAVURU Padmini |
分类号 |
A61K31/197;A61K47/12;A61K9/00 |
主分类号 |
A61K31/197 |
代理机构 |
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代理人 |
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主权项 |
1. A pharmaceutically acceptable salt of β-guanidinopropionic acid, wherein said pharmaceutically acceptable salt is a 2:1 succinate salt. |
地址 |
New York NY US |