发明名称 |
METHOD FOR IMPROVING PROTEIN EXPRESSION, AND COMPOSITION FOR PROTEIN EXPRESSION |
摘要 |
The present invention provides a method for improving protein expression and a composition for protein expression. The composition is a composition for use in expressing a target protein, the composition comprising an mRNA encoding the target protein, wherein 80% or more of the mRNA molecules contained in the composition have a sequence consisting substantially of poly(A) having a length of 230 to 250 nucleotides on the 3'-end side of the protein-coding region thereof. |
申请公布号 |
EP3135763(A1) |
申请公布日期 |
2017.03.01 |
申请号 |
EP20150782362 |
申请日期 |
2015.04.23 |
申请人 |
Accurna, Inc. |
发明人 |
ITAKA, Keiji;KATAOKA, Kazunori;IKEGAMI, Masaru;UCHIDA, Satoshi;UCHIDA, Hirokuni;NAGATA, Kazuya |
分类号 |
C12N15/09;A61K31/7105;A61K48/00;A61P25/00;A61P25/02;A61P43/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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