发明名称 |
PROCESSES FOR THE PREPARATION OF CRYSTALS INCLUDING A MALIC ACID SALT OF N-[2-(DIETHYLAMINO)ETHYL]-5-[(5-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOLE-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE. |
摘要 |
The present invention provides crystals, and compositions thereof, wherein the crystals include a malic acid salt of N-[2-(diethylamino)ethyl]5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide. Methods of preparing such crystals are also disclosed. |
申请公布号 |
EP2332934(B1) |
申请公布日期 |
2017.03.01 |
申请号 |
EP20110156767 |
申请日期 |
2002.08.13 |
申请人 |
Pharmacia & Upjohn Company LLC |
发明人 |
Hawley, Michael;Fleck, Thomas, J.;Prescott, Stephen, P.;Maloney, Mark, T. |
分类号 |
C07D403/06;A61K31/404;A61P17/06;A61P35/00;A61P35/02;A61P43/00;C07C59/245;C07D |
主分类号 |
C07D403/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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