SET OF OLIGONUCLEOTIDES AND METHOD FOR DETECTION OF FETAL DNA FRACTION IN MATERNAL PLASMA

摘要

A method for calculating the fetal ccfDNA fraction in maternal plasma comprising detecting the presence of fetus specific alleles (different from maternal alleles) of composition of common single nucleotide polymorphism (SNP) in a target polynucleotide in a subject, wherein the SNP comprises rs10873704, rs2316921, rs3991951, rs13142086, rs2598548, rs10155423, rs7683293, rs11132694, rs2287678, rs888726, rs7740992, rs11242795, rs7756422, rs6915731, rs9347210, rs9691429, rs4875906, rs10780162, rs2005486, rs3911483, rs2028902, rs2904516, rs2175938, rs1973118, rs6498782, rs3826238, rs11568105, rs2139261, rs4494584 and rs55969137, and wherein detecting the presence of the fetal specific alleles (different from maternal alleles) of SNP in the subject is indicative of the fetal ccfDNA fraction in maternal plasma.