OPTOGENETIC ANALYSIS OF COMPOUNDS

摘要

Disease models for Parkinson's disease are disclosed comprising a dopaminergic neuron having one or more phenotypic or genotypic characteristics of Parkinson's disease where the neuron expresses an optical reporter of, and an optical activator of, electrical activity and that exhibits an optical signature in response to neural stimulation. Cells may optionally include an indicator of intracellular calcium levels. Transformed neurons may be optically evaluated for action potentials to track the development of disease, evaluate potential therapies, diagnosis of disease, and to identify mutations and genes associated with disease development and progression.