发明名称 Process for preparing inhibitors of nucleoside metabolism
摘要 The invention provides a compound of the formula: wherein Y is an unsubstituted or substituted alkyl or arylalkyl group having 1 to 8 carbon atoms, as well as a process of preparing said compound. The invention also provides a process of preparing the compound 3H,5H-pyrrolo[3,2-d]pyrimidin-4-one, comprising the step of reacting a compound of the formula (A) defined above with a reagent capable of delivering a formyl equivalent. The invention also provides a process of preparing the compound 2-amino-3 H ,5 H -pyrrolo[3,2- d ]pyrimidin-4-one, comprising the step of reacting the compound 2-(N-dimethylaminomethylene)amino-6-(2-dimethylaminovinyl)-5-nitropyrimid-4-one with a reagent capable of reducing the nitro group, to produce the compound 2-amino-3 H ,5 H- pyrrolo[3,2- d ]pyrimidin-4-one.
申请公布号 EP2077268(B1) 申请公布日期 2017.03.01
申请号 EP20090150953 申请日期 2000.04.07
申请人 Victoria Link Limited;Albert Einstein College of Medicine, Inc. 发明人 Furneaux, Richard Hubert;Tyler, Peter Charles;Schramm, Vern L.
分类号 C07D487/04;A61K31/519;A61P31/00;A61P43/00;C07D207/34;C07D207/40;C07D207/416;C07D519/00;C07F7/18;C07H19/14 主分类号 C07D487/04
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