发明名称 |
MDA-9/SYNTENIN PROMOTER TO IMAGE AND TREAT METASTATIC CANCER CELLS |
摘要 |
Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by an mda-9/syntenin (mda-9) cancer selective promoter are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, especially to visualize (image) and treat metastasis (including in rapid in vitro assays), and the transgenic mice are used to monitor cancer progression and/or the efficacy of candidate therapeutic agents in screening assays. |
申请公布号 |
EP3004872(A4) |
申请公布日期 |
2017.03.01 |
申请号 |
EP20140807809 |
申请日期 |
2014.06.04 |
申请人 |
Virginia Commonwealth University |
发明人 |
FISHER, Paul, B.;DAS, Swadesh, K.;MENEZES, Mitchell, D.;SARKAR, Devanand |
分类号 |
G01N33/48;A61K49/00;C07K14/00;C12N15/86;G01N33/574 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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