发明名称 |
METHOD FOR FORMULATING A VACCINE CONTAINING AT LEAST TWO ANTIGENS CAPABLE OF ADSORBING ONTO ALUMINIUM OXYHYDROXIDE |
摘要 |
The subject matter of the invention is a method for preparing a vaccine composition comprising at least aluminum oxyhydroxide (AlOOH), and at least the hepatitis B surface antigen and the Haemophilus influenzae type b antigen. According to the invention, the hepatitis B surface antigen is kept adsorbed on the AlOOH, whereas the Hib antigen is kept nonadsorbed. To this end: the hepatitis B surface antigen is adsorbed onto AlOOH in order to obtain an AlOOH/HBsAg complex, then—said AlOOH/HBsAg complex is mixed with the Hib antigen in the presence of cationic amino acids at a concentration of at least 100 mg/l, and of phosphate ions at a concentration of 35 to 45 mMol/l. |
申请公布号 |
EP2804628(B1) |
申请公布日期 |
2017.03.01 |
申请号 |
EP20130704171 |
申请日期 |
2013.01.17 |
申请人 |
Sanofi Pasteur |
发明人 |
BERTAUX, Landry;CHACORNAC, Isabelle;FRANÇON, Alain;HAU, Jean-François;LENTSCH GRAF, Sandrine |
分类号 |
A61K39/295;A61P31/04;A61P31/12 |
主分类号 |
A61K39/295 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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