COUPLING OF BORRELIAL PROTEIN BB0689 TO VIRUS-LIKE PARTICLES FOR GENERATION OF LYME DISEASE VACCINE

摘要

An invention discloses Lyme disease vaccine by obtaining high immune response against surface protein BB069 from Borrelia burgdorferi, the causative agent of Lyme disease. Present invention includes a protein comprising amino acids identical at least 80% to modified Borrelia burgdorferi BB0689 protein (as set forth in SEQ ID 5), chemically coupled to bacteriophage Q² virus-like particles. Said invention also relates with a method of production and purification of protein, comprising amino acids identical at least 80% to modified Borrelia burgdorferi BB0689 protein as set forth in SEQ ID 5.