COSMETIC SKIN WHITENING COMPOSITIONS CONTAINING EXTRACTS DERIVED FROM IN VITRO PROPAGATED HYPERICUM HIRSUTUM

摘要

The present invention relates to extract containing active substances and use of extract as active ingredient for skin whitening cosmetic formulations. A skin whitening cosmetic active ingredient based on extract derived from in vitro cultivated Hypericum hirsutum by 50% ethanol extraction is proposed. Invention relates specifically to the plant material derived from in vitro shoot cultures with no growth regulators added. The offered ingredient contains Kaempferol-3-O-glucoside, Kaempferol-7-O-glucoside, Fisetin, Chlorogenic acid, 3-Caffeoylquinic acid and Umbelliferone. Invention proposes use of extract, which exhibits anti-proliferative effect on melanocytes and is not highly cytotoxic in concentration range of 1 -3 %, as active ingredient in skin whitening cosmetic formulations. The proposed concentration range for use in cosmetic formulations is 0.5-2% (v/v).