Methods and compositions for the generation and maintenance of regulatory T cells

摘要

Methods and compositions for generating and maintaining induced regulatory T cells (iTregs) are provided. Methods and compositions for treating an autoimmune disorder, organ transplant rejection, graft versus host disease or allergic or hypersensitivity and inflammation are also provided.

主权项

1. A method of generating an induced regulatory T cell (iTreg) comprising the steps of:
a) isolating a CD4+ Foxp3− naïve T cell; b) contacting the isolated naïve T cell with PD-L1 and/or PD-L2; and c) examining the T cell for Foxp3 expression and/or the ability to suppress effector T cell (Teff) activation, wherein Foxp3 expression and/or the ability to suppress Teff activation is indicative of an iTreg.