| 发明名称 | Polyionic papilloma virus-like particle (VLP) vaccines | ||
| 摘要 | The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle (VLP) vaccines. In one embodiment, a chimeric papillomavirus virus-like particle (VLP) comprises the L1 protein, wherein the HI loop of the L1 protein comprises negatively charged amino acids. In a more specific embodiment, a chimeric bovine papillomavirus VLP comprises the L1 protein, wherein the amino acid sequence EEEEEEEEC is inserted into the HI loop of the L1 protein. | ||
| 申请公布号 | US9580474(B2) | 申请公布日期 | 2017.02.28 |
| 申请号 | US201113821579 | 申请日期 | 2011.09.08 |
| 申请人 | THE JOHNS HOPKINS UNIVERSITY | 发明人 | Viscidi Raphael Paul;Bossis Ioannis |
| 分类号 | A61K39/12;C07K14/025;C07K14/005;A61K39/00;A61K47/48 | 主分类号 | A61K39/12 |
| 代理机构 | Johns Hopkins Technology Transfer | 代理人 | Johns Hopkins Technology Transfer |
| 主权项 | 1. A vaccine comprising: (a) a chimeric papillomavirus virus-like particle (VLP) comprising a L1 protein, wherein an amino acid sequence EEEEEEEEC (SEQ ID NO: 11) is inserted into the HI loop of the L1 protein; and (b) a target antigen other than the L1 protein, wherein the target antigen comprises a region of positively charged amino acids, and wherein the amino acid sequence EEEEEEEEC (SEQ ID NO: 11) of the HI loop of the L1 protein is covalently bound to the positively charged region of the target antigen. | ||
| 地址 | Baltimore MD US | ||