Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors

摘要

Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N—H, N—(C1-C10 alkyl) or S; each X is independently CH or N; R1 is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R2 is (LQ)mY; and each R3 is independently H, C1-C10 alkyl, aryl or heteroaryl, are surprisingly found to be inhibitors of PI3K-p110δ, and therefore have utility in therapy.;

主权项

1. A compound represented by formula I:or a pharmaceutically acceptable salt thereof, wherein:
W is O; X is CH; R2 is (LQ)mY; m is 1; L is C1alkylene: Q is selected from the group consisting of: a direct bond, —NR3—, and a heterocyclic linker; Y is selected from the group consisting of: H, C1-10alkyl, —OR3, and —C(O)N(R3)2; and R3 is independently selected for each occurrence from H or C1-C10 alkyl.