| 发明名称 | Meningococcal fHBP polypeptides | ||
| 摘要 | fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal. | ||
| 申请公布号 | US9579372(B2) | 申请公布日期 | 2017.02.28 |
| 申请号 | US200912918729 | 申请日期 | 2009.02.20 |
| 申请人 | GlaxoSmithKline Biologicals SA | 发明人 | Pizza Mariagrazia;Scarselli Maria;Giuliani Marzia Monica;Arico Maria;Rappuoli Rino |
| 分类号 | A61K39/095;A61K39/02;A61K39/38;A61K38/00;C07K1/00;C07H21/04;C12N15/00;C07K14/22;A61K39/00 | 主分类号 | A61K39/095 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. An immunogenic composition comprising (a) an isolated polypeptide comprising an amino acid sequence (i) which has at least 94% sequence identity to SEQ ID NO: 76 and/or (ii) comprises a first fragment and a second fragment of SEQ ID NO: 76, wherein said first fragment includes at least 28 contiguous amino acids from within amino acids 89-154 of SEQ ID NO: 76, and said second fragment includes at least 28 contiguous amino acids from within amino acids 187-248 of SEQ ID NO: 76, and (b) an immunostimulatory amount of an aluminium salt adjuvant. | ||
| 地址 | Rixensart BE | ||