Methods of treating obstructive lung diseases using bitter tastants

摘要

Described herein are methods for enhancing airway dilation and/or relieving bronchoconstriction, e.g., to treat obstructive lung diseases such as asthma and COPD, by administering bitter tastants to subjects in need thereof. Also described herein are methods for identifying compounds that modulate function of bitter tastant receptors.

主权项

1. A method of treating asthma in a subject, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a bitter tastant to a subject in need of treatment and having asthma, wherein the bitter tastant is selected from the group consisting of aristocholic acid, saccharin, and salicin, thereby treating the obstructive lung disease in the subject.