发明名称 |
Methods and compositions for treating malignant tumors associated with KRAS mutation |
摘要 |
This invention provides methods and compositions for preventing, treating or ameliorating one or more symptoms of a malignant tumor associated with KRAS mutation in a mammal in need thereof, by identifying a tumor cell in the mammal, the tumor cell comprising at least one of: (i) a mutation of the KRAS gene, and (ii) an aberrant expression level of KRAS protein; and administering to the mammal a therapeutically effective amount of a composition comprising one or more RNAi molecules that are active in reducing expression of GST-π. |
申请公布号 |
US9580710(B2) |
申请公布日期 |
2017.02.28 |
申请号 |
US201514979573 |
申请日期 |
2015.12.28 |
申请人 |
Nitto Denko Corporation |
发明人 |
Minomi Kenjirou;Liu Jihua;Wang Li;Majeti Bharat;Adami Roger;Ying Wenbin |
分类号 |
C07H21/02;A61K48/00;C12N15/113 |
主分类号 |
C07H21/02 |
代理机构 |
Eckman Law Group |
代理人 |
Eckman Law Group |
主权项 |
1. A pharmaceutical composition for the treatment or therapy of a tumor associated with a mutation in the KRAS gene or overexpression of wild-type KRAS gene, the composition comprising RNAi molecules and pharmaceutically acceptable excipients, wherein the RNAi molecules comprise an antisense strand which comprises SEQ ID NO: 184 and a sense strand which comprises SEQ ID NO: 158. |
地址 |
Osaka JP |