| 发明名称 | Expanding the eukaryotic genetic code | ||
| 摘要 | This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided. | ||
| 申请公布号 | US9580721(B2) | 申请公布日期 | 2017.02.28 |
| 申请号 | US201414574257 | 申请日期 | 2014.12.17 |
| 申请人 | The Scripps Reserach Institute | 发明人 | Chin Jason W.;Cropp T. Ashton;Anderson J. Christopher;Schultz Peter G. |
| 分类号 | C12N15/81;A61K38/17;C12N9/00;C12N15/67 | 主分类号 | C12N15/81 |
| 代理机构 | Quine Intellectual Property Law Group, P.C. | 代理人 | Quine Intellectual Property Law Group, P.C. |
| 主权项 | 1. A eukaryotic cell comprising an orthogonal aminoacyl-tRNA synthetase (O-RS), wherein the O-RS comprises an amino acid sequence as set forth in any one of SEQ ID NO: 36-47, or 86. | ||
| 地址 | La Jolla CA US | ||