| 摘要 |
The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1);wherein Rand Rare aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is -NH-G-, -N(lower alkyl)-G-, -NH-CH-G-, -N(lower alkyl)-CH-G- or -CH-G- [wherein Gbinds to R, G-Ris bond-R, phenylene-G-R, phenylene-G-O-R, phenylene-G-NH-R, phenylene-G-N(lower alkyl)-Ror quinolinediyl-O-R, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G-Ris -O-lower alkylene-Ror the like; G-O- is lower alkylene-O- or the like; Gis lower alkylene; Gis lower alkylene]. |
