Miniaturized flow-through cell

摘要

The present disclosure relates to a diffusion cell for testing the permeation of a compound(s) across a membrane. Also, the present disclosure relates to a method of manufacturing a diffusion cell. Further, the present disclosure relates to a method of performing an assay using a diffusion cell.

主权项

1. A diffusion cell comprising:
a donor compartment; a receptor compartment comprising a cavity extending along a vertical axis of the receptor compartment, a first opening and a second opening, the donor compartment being insertable into and removable from the cavity of the receptor compartment; and a tube passing through and generally perpendicular to the vertical axis of the receptor compartment, the tube comprising a length, a first end and a second end, a wall extending from the first end to the second end, a channel defined by the wall, and a slit in the wall, the tube configured for fluid flow along the channel from the first end towards the second end, wherein the first end of the tube extends through the first opening of the receptor compartment, and the second end of the tube extends through the second opening of the receptor compartment.