Collagen scaffolds, medical implants with same and methods of use

摘要

The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. A specific embodiment of the invention concerns implantable glucose sensors. Sensors comprising a collagen scaffold of the invention have improved biocompatibility by minimizing tissue reactions while stimulating angiogenesis. The subject invention also concerns methods for preparing collagen scaffolds of the invention. The subject invention also concerns sensors that have a collagen scaffold of the invention around the exterior of the sensor.

主权项

1. A method for preparing a device for implantation into the body or tissue of a person or animal, said method comprising placing a biocompatible collagen scaffold or coating on said device, wherein said collagen scaffold or coating comprises regularly distributed open pores and an interconnected pore structure and is imbedded in a nordihydroquaiaretic acid (NDGA) bisquinone polymer matrix, and wherein said open pores are between about 10 um to about 200 um in diameter (mean).