Lanthanoid complex capsule and particle contrast agents, methods of making and using thereof

摘要

The invention relates to compositions of DOTA derivative compounds, lanthanoid-DOTA derivative molecular complex, and lanthanoid-complex encapsulated solid lipid particles or capsules, and methods of making and using the compositions. The solid lipid particles or capsules contain micelle cores stabilized by a hyperbranched polymer shell based from a crosslinked DOTA derivative compound or crosslinked lanthanoid-DOTA derivative complex. These solid lipid particles or capsules can be used in various applications, such as contrast agents or drug delivery vehicles.

主权项

1. A hyperbranched polymer nanoparticle or nanocapsule comprising:
hyperbranched polymeric unit having formula (IV):and optionally a crosslinking moiety CL,
wherein: R is H or a cation; X is O or S; n is 1-10; p is the number of the units of formula (IV) ranging from 2 to 200,000; and crosslinking moiety CL, if present, is a moiety connecting the hyperbranched polymeric units together through covalently bonding to each X of formula (IV).