发明名称 |
Water-soluble ursodeoxycholic acid prodrugs |
摘要 |
Ursodeoxycholic acid (UDCA) is a bile acid with demonstrated anti-apoptotic activity in both in vitro and in vivo models. Water-soluble prodrugs of UDCA for use in indications where intravenous administration of UDCA may be preferable, such as reducing damage from stroke or acute kidney injury, are disclosed. The disclosed prodrugs showed significant anti-apoptotic activity in a series of in vitro assays. |
申请公布号 |
US9580459(B2) |
申请公布日期 |
2017.02.28 |
申请号 |
US201414261963 |
申请日期 |
2014.04.25 |
申请人 |
Metselex, Inc. |
发明人 |
Dosa Peter Ian;Steer Clifford John;Georg Ingrid Gunda |
分类号 |
C07J51/00 |
主分类号 |
C07J51/00 |
代理机构 |
Kinney & Lange, P.A. |
代理人 |
Kinney & Lange, P.A. |
主权项 |
1. A compound having the general formula or a pharmaceutically acceptable salt thereof. |
地址 |
Minneapolis MN US |