VHZ for diagnosis and treatment of cancers

摘要

We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer in an individual selected from the group consisting of: colon cancer, lung cancer, squamous cell carcinoma including lip, larynx, vulva, cervix and penis cancer, pancreatic cancer, brain cancer, oesophageal cancer, stomach cancer, bladder cancer, kidney cancer, skin cancer, ovary cancer, prostate cancer and testicular cancer. We provide an anti-VHZ agent for the treatment, prophylaxis or alleviation of such a cancer. The anti-VHZ agent may comprise SEQ ID NO:4 or SEQ ID NO: 5, or both.

主权项

1. A method of treatment of a metastatic cancer in which VHZ is overexpressed in a subject, said method comprising administering an anti-VHZ antibody or a fragment thereof that binds to a VHZ polypeptide comprising the amino acid sequence of SEQ ID NO: 2 to the subject, wherein said anti-VHZ antibody or fragment thereof:
comprises VH domain comprising the amino acid sequence of SEQ ID NO: 4 and a VL domain comprising the amino acid sequence of SEQ ID NO: 5; and inhibits tumor formation by VHZ expressing human tumor cells in a nude mouse model.