Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use

摘要

The present invention relates to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) mutant strains having increased stability; compositions containing the strains or antigens derived therefrom; vaccines containing the strains, including killed, attenuated or subunit vaccines; nucleic acids encoding PRRSV polypeptides, polypeptides encoded by the nucleic acids, including antigenic fragments thereof; antibodies which specifically bind to said polypeptides, and methods making and using thereof.

主权项

1. An immunogenic composition of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), comprising at least one of
a) a composition comprising SEQ ID NO:2 (attenuated Wetzel p41); or b) a polypeptide selected from the group consisting of
i) SEQ ID NO:9 (M protein of Wetzel p3 and of Wetzel p41),ii) SEQ ID NO:10 (N protein of Wetzel p3and of Wetzel p41),iii) SEQ ID NO:11 (ORF1a protein of Wetzel p41),iv) SEQ ID NO:12 ORF1b protein of Wetzel p41),v) SEQ ID NO:13 (GP2 protein of Wetzel p41),vi) SEQ ID NO:14 (GP3 protein of Wetzel p41), andvii) SEQ ID NO:15 (GP5 protein of Wetzel p41).