Pharmaceutical composition for application to nail

摘要

Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.

主权项

1. A pharmaceutical composition for nail consisting of an antifungal drug, alkylpyrrolidone or a derivative thereof, and a single crosslinking hydrogel,
wherein the antifungal drug is one or more selected from the group consisting of lanoconazole, clotrimazole, and bifonazole, and a content of the antifungal drug in the pharmaceutical composition is 1 to 5%, the alkylpyrrolidone is N-methyl-2-pyrrolidone and a content of the alkylpyrrolidone in the pharmaceutical composition is 1 to 20%, the single crosslinking hydrogel consists of 1 to 30% of a water-soluble crosslinking polymer, 1 to 50% of a polyvalent alcohol, 1 to 10% of an adhesion enhancer, 0.1 to 1% of a crosslinking agent, and 20 to 80% of water, and the pharmaceutical composition further comprises one or more ingredients selected from the group consisting of a pH adjusting agent, a thickener, a moisture adjuster, an absorption enhancer, and a surfactant.