摘要 |
The present invention relates to obeticholic acid: or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing HDL cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of obeticholic acid. |
申请人 |
INTERCEPT PHARMACEUTICALS, INC. |
发明人 |
STEINER, ANDRÉ;WAENERLUND POULSEN, HEIDI;JOLIBOIS, EMILIE;REWOLINSKI, MELISSA;GROSS, RALF;SHARP, EMMA;DUBAS-FISHER, FIONA;EBERLIN, ALEX |