发明名称 |
Microrna compounds and methods for modulating mir-21 activity |
摘要 |
Described herein are compositions and methods for the inhibition of miR-21 activity. A compound comprising a modified oligonucleotide consisting of 8 to 22 linked nucleosides, wherein the nucleobase sequence of the modified oligonucleotide is complementary to miR-21 (SEQ ID NO: 1) and wherein the modified oligonucleotide comprises at least 8 contiguous nucleosides of the following nucleoside pattern VI, III or IV in the 5’ to 3’ orientation. |
申请公布号 |
NZ630591(A) |
申请公布日期 |
2017.02.24 |
申请号 |
NZ20130630591 |
申请日期 |
2013.04.24 |
申请人 |
Regulus Therapeutics Inc. |
发明人 |
Bhat Balkrishen;Marcusson Eric |
分类号 |
C12N15/113;A61K31/712;A61P13/12;A61P35/00;A61P43/00 |
主分类号 |
C12N15/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|