| 摘要 |
Disclosed is a method for predicting deficiency in the DNA homologous recombination (HR) pathway in a patient suffering from cancer, comprising the step of quantifying the number of rearrangements in the genomic DNA of a tumour sample obtained from said patient, wherein the number of rearrangements corresponds to the number, per genome, of breakpoints resulting in segments of at least 3 megabases, further comprising the step of comparing the number of rearrangements per genome to a threshold, wherein a number of rearrangements per genome superior to said threshold is indicative of HR deficiency. |
