The present invention relates to ethynyl derivatives of formula I wherein R1 is phenyl, which is optionally substituted by 1-2 halogen atoms; selected from fluorine or chlorine; or to a pharmaceutically acceptable acid addition salt in enantiomerically pure form. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
申请公布号
HRP20161691(T1)
申请公布日期
2017.02.24
申请号
HR2016P001691T
申请日期
2016.12.12
申请人
F. Hoffmann - La Roche AG
发明人
Jaeschke, Georg;Lindemann, Lothar;Stadler, Heniz;Vieira, Eric