发明名称 |
DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE |
摘要 |
The invention relates to compounds of a general formula (I):
wherein Ar 1 is an optionally-substituted aryl or heteroaromatic group; R 1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R 2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R 3 is a hydrogen atom or a lower alkyl group; R 4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of -N(R 1k )R 1m ; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers. |
申请公布号 |
HRP20161763(T1) |
申请公布日期 |
2017.02.24 |
申请号 |
HR2016P001763T |
申请日期 |
2016.12.21 |
申请人 |
MSD K.K. |
发明人 |
Sakamoto, Toshihiro;Sunami, Satoshi;Yamamoto, Fuyuki;Niiyama, Kenji;Bamba, Makoto;Takahashi, Keiji;Furuyama, Hidetomo;Goto, Yasuhiro;Sagara, Takeshi;Otsuki, Sachie;Nishibata, Toshihide;Yoshizumi, Takashi;Hirai, Hiroshi |
分类号 |
C07D471/04;A61K31/519;A61K31/5377;A61K31/54;A61K31/551;A61P35/00;A61P43/00;C07D487/04 |
主分类号 |
C07D471/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|