发明名称 |
Selective Chemotherapy Treatments and Diagnostic Methods Related Thereto |
摘要 |
This disclosure relates to methods of identifying subjects that have an increased likelihood of responding to a combination of a poly (ADP) ribose polymerase enzyme inhibitor and a platinum based reagent and optionally other anticancer agents in the course of chemotherapy. In certain embodiments, the disclosure relates to methods of treating cancer comprising administering an effective amount of a poly (ADP) ribose polymerase enzyme inhibitor and a platinum based reagent to the subject in need thereof, wherein the subject is in need thereof because measuring a quantity of RNA isolated from a cancer cell from the subject indicates an increased quantity of the RNA compared to a normal sample, wherein the RNA is associated with one or more of the following genes/pseudogenes GLS, UBEC2, HACL1, MSI2, and LOC100129585. |
申请公布号 |
US2017049815(A1) |
申请公布日期 |
2017.02.23 |
申请号 |
US201515308493 |
申请日期 |
2015.05.01 |
申请人 |
Emory University |
发明人 |
Owonikoko Taofeek Kunle |
分类号 |
A61K33/24;C12Q1/68;A61K31/7048;A61K31/4184 |
主分类号 |
A61K33/24 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating cancer comprising administering an effective amount of a poly (ADP) ribose polymerase enzyme inhibitor and a platinum based reagent to the subject in need thereof, wherein the subject is in need thereof because measuring a quantity of RNA isolated from a cancer cell from the subject indicates an increased quantity of the RNA compared to a normal sample, wherein the RNA is associated with one or more of the following genes GLS, UBEC2, HACL1, MSI2, and LOC100129585. |
地址 |
Atlanta GA US |