| 摘要 |
Anticancer compound FD-2 drug intermediate 2-n-butoxy-5-amino-pyrimidin-4-one synthesis method , comprising the following steps: the reaction vessel was added 0.16mol n-butylamine (3), 130ml cyclohexane, the solution temperature is raised to 60-65 C, 0.49 mol cuprous chloride was added in batches, controlled the stirring speed 130-160rpm, after 60-80 min, added 0.17-0.19mol 2-hydroxy-5-amino-pyrimidin-4-one solution (2), refluxed for 4-5 h, cyclohexane was distilled off under reduced pressure, 310ml potassium chloride solution was added, the solution temperature is reduced to 10 15 C, oxalic acid solution was added to adjust pH to 1-2, whereupon white crystals precipitated, filtered, washed with salt solution, dehydrated with dehydrating agent, washed with propionitrile solution, recrystallized from nitromethane solution, got crystals of 2-n-butoxy-5-amino-pyrimidin-4-one. |
