| 主权项 |
1. A chimeric antigen receptor (CAR) comprising:
a) an extracellular domain that binds one or more epitopes of a human kappa light chain polypeptide; b) a transmembrane domain derived from a polypeptide selected from the group consisting of: CD8a; CD4, CD45, PD1, and CD152; c) one or more intracellular co-stimulatory signaling domains selected from the group consisting of: CD28, CD54 (ICAM), CD134 (OX40), CD137 (41BB), CD152 (CTLA4), CD273 (PD-L2), CD274 (PD-L1), and CD278 (ICOS); and d) a CD3ζ primary signaling domain. |
