发明名称 |
USE OF VDAS TO ENHANCE IMMUNOMODULATING THERAPIES AGAINST TUMORS |
摘要 |
Methods for producing an anti-tumor effect in a subject suffering from a cancer or a tumor are disclosed. The methods comprise administering to the patient a Vascular Disrupting Agent (VDA) that a combretastatin agent and one or more antibodies selected from the group consisting of: a CTLA-4 antibody, a PD- 1 antibody, a PD-L1 antibody, and a PD-L2 antibody in amounts effective therefor. Examples of combretastatin include CA 1 P, CA4P, and their corresponding salts and prodrugs. The combination of the VDA and one or more of the antibodies produced a synergistic anti-tumor effect. |
申请公布号 |
WO2017031157(A1) |
申请公布日期 |
2017.02.23 |
申请号 |
WO2016US47267 |
申请日期 |
2016.08.17 |
申请人 |
MATEON THERAPEUTICS, INC. |
发明人 |
CHAPLIN, David, J.;PERKINS, Kimberly |
分类号 |
A61K38/12;A61K31/661 |
主分类号 |
A61K38/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|