POLYMERIC MATERIALS FOR BIO-APPLICATIONS

摘要

A composition comprising a biodegradable polymeric material and therapeutic agent associated with the polymeric material that advantageously can provide controlled release of the therapeutic agent, while comprising little to no auxiliary materials. In some embodiments, the composition is formed by the reaction of one or more monomers in the presence of a food grade catalyst. In another embodiment, the composition comprises a polymeric material capable of undergoing thermal reconfiguration (i.e. a dynamic network). Advantageously, the compositions and materials described herein may comprise a reconfigurable polymeric material (e.g., a thermoset polymeric material) having the strength and integrity of epoxy resins, the biomedical applicability of hydrogels, and/or the moldability of vitrimers.

主权项

1. A composition, comprising:
a crosslinked polymeric material and an active substance associated with the material; wherein the crosslinked polymeric material comprises a polymer backbone and between 1 mol % and 25 mol % with respect to polymer agent a food grade catalyst, inclusive; wherein the active substance is present in the composition in an amount of at least about 0.1 wt % based on the weight of the composition; and wherein the composition comprises less than about 10 wt % auxiliary materials other than the crosslinked polymeric material, food grade catalyst, and the active substance, based on the weight of the composition.